Protein Details: Voltage-gated hydrogen channel 1

Function

Voltage-gated proton-selective channel that conducts outward proton currents in response to intracellular acidification. Lacks a canonical ion-channel pore domain and mediates proton permeability via its voltage sensor domain.<br /> Provides for proton efflux that compensates for electron charge generated by NADPH oxidase activity either in the extracellular or phagosomal compartments; thus enabling the production of high levels of bactericidal reactive oxygen species during the respiratory burst.

Sequence

PDB Structures

Ligand Binding